Glycolytic flux-signaling controls mouse embryo mesoderm development
How cellular metabolic state impacts cellular programs is a Pencils fundamental, unresolved question.Here, we investigated how glycolytic flux impacts embryonic development, using presomitic mesoderm (PSM) patterning as the experimental model.First, we identified fructose 1,6-bisphosphate (FBP) as an in vivo sentinel metabolite that mirrors glycoly